First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia
نویسندگان
چکیده
BACKGROUND First trimester Pregnancy Associated Plasma Protein A (PAPP-A) levels, routinely measured for aneuploidy screening, may predict development of preeclampsia. This study tests the hypothesis that first trimester PAPP-A levels correlate with soluble fms-like tyrosine kinase-1 (sFlt-1) levels, an angiogenic marker associated with preeclampsia, throughout pregnancy. METHODS sFlt-1 levels were measured longitudinally in 427 women with singleton pregnancies in all three trimesters. First trimester PAPP-A and PAPP-A Multiples of Median (MOM) were measured. Student's T and Wilcoxon tests compared preeclamptic and normal pregnancies. A linear mixed model assessed the relationship between log PAPP-A and serial log sFlt-1 levels. RESULTS PAPP-A and PAPP-A MOM levels were significantly lower in preeclamptic (n = 19), versus normal pregnancies (p = 0.02). Although mean third trimester sFlt-1 levels were significantly higher in preeclampsia (p = 0.002), first trimester sFlt-1 levels were lower in women who developed preeclampsia, compared with normal pregnancies (p = 0.03). PAPP-A levels correlated significantly with serial sFlt-1 levels. Importantly, low first trimester PAPP-A MOM predicted decreased odds of normal pregnancy (OR 0.2, p = 0.002). CONCLUSIONS Low first trimester PAPP-A levels suggests increased future risk of preeclampsia and correlate with serial sFlt-1 levels throughout pregnancy. Furthermore, low first trimester PAPP-A status significantly predicted decreased odds of normal pregnancy.
منابع مشابه
First Trimester Papp-a Levels Correlate with Sflt-1 Levels Longitudinally in 1 Pregnant Women with and without Preeclampsia
FIRST TRIMESTER PAPP-A LEVELS CORRELATE WITH SFLT-1 LEVELS LONGITUDINALLY IN 1 PREGNANT WOMEN WITH AND WITHOUT PREECLAMPSIA 2 3 Aditi R. Saxena 1 , Ellen W. Seely 1 , Janet W. Rich-Edwards 1 , Louise E. Wilkins-Haug 2 , S. Ananth 4 Karumanchi 3 , and Thomas F. McElrath 2 5 1 Department of Medicine, Brigham and Women’s Hospital, Boston, MA 6 2 Department of Obstetrics and Gynecology, Brigham and...
متن کاملAuthor's response to reviews Title: First Trimester PAPP-A Levels Correlate with sFlt-1 Levels Longitudinally in Pregnant Women with and without Preeclampsia Authors:
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